Ak9 Gene Summary [Mouse]
Predicted to enable (d)CMP kinase activity; UMP kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in CDP biosynthetic process and UDP biosynthetic process. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; lung; and rib. Used to study normal pressure hydrocephalus. Human ortholog(s) of this gene implicated in spermatogenic failure 89. Orthologous to human AK9 (adenylate kinase 9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ak9 |
| Official Name | adenylate kinase 9 [Source:MGI Symbol;Acc:MGI:2685080] |
| Ensembl ID | ENSMUSG00000091415 |
| Bio databases IDs | |
| Aliases | adenylate kinase 9 |
| Synonyms | adenylate kinase 9, AKD1, AKD2, C6ORF199, C6orf224, dJ70A9.1, FLJ42177, Gm234, Gm7127, RGD1559879, RGD1560386, SPGF89 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ak9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- nucleoside diphosphate kinase
- nucleoside-phosphate kinase
- NK
- adenylate kinase, isozyme 1 subfamily
- N-terminal helicase domain of the DEAD-box helicase superfamily
- YHS
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Ak9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- Cytoplasm
- cilia
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ak9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleoside monophosphate phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleoside phosphate kinase activity
- ATPase activity
- adenylate kinase activity
- ATP binding
- nucleoside diphosphate kinase activity