Myo9a Gene Summary [Mouse]
Predicted to enable actin filament binding activity and microfilament motor activity. Involved in postsynaptic specialization organization and regulation of neuron projection arborization. Located in axonal growth cone. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Used to study focal segmental glomerulosclerosis and obstructive hydrocephalus. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to human MYO9A (myosin IXA). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo9a |
| Official Name | myosin IXa [Source:MGI Symbol;Acc:MGI:107735] |
| Ensembl ID | ENSMUSG00000039585 |
| Bio databases IDs | |
| Aliases | myosin IXa |
| Synonyms | 4732465J09RIK, C130068I12RIK, C230003M11, CMS24, myosin IXA, myr 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myo9a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD)
- Myosin and Kinesin motor domain
- GTPase activator
- enzyme
- protein binding
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- IQ calmodulin-binding motif
- Myosin head (motor domain)
- Calmodulin-binding motif
- Ubl1_cv_Nsp3_N-like
- protein kinase C conserved region 1 (C1 domain) superfamily
- Myosin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- presynaptic congenital myasthenic syndrome type 24
- growth failure
- gout
- obstructive hydrocephalus
- systemic lupus erythematosus
- tumorigenesis
- arthrogryposis
- aortic valve calcification
- gait disturbance
regulates
role in cell
- migration
- formation
- scattering
- cell-cell adhesion
- assembly
- invasion by
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- axon component
- postsynaptic region
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myo9a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- establishment of epithelial cell apical/basal polarity
- visual perception
- cell junction assembly
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- axonal growth cone
- membrane
- unconventional myosin complex
- cytosol
- synapse
- actin filament
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- protein binding
- metal ion binding
- GTPase activator activity
- microfilament motor activity