Lrrc23 Gene Summary [Mouse]

Involved in flagellated sperm motility and radial spoke assembly. Located in sperm flagellum. Is active in cytosol. Is expressed in lung; lung epithelium; nasal cavity respiratory epithelium; nasal epithelium; and palatal shelf mesenchyme. Human ortholog(s) of this gene implicated in spermatogenic failure 92. Orthologous to human LRRC23 (leucine rich repeat containing 23). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Lrrc23
Official Name
leucine rich repeat containing 23 [Source:MGI Symbol;Acc:MGI:1315192]
Ensembl ID
ENSMUSG00000030125
Bio databases IDs NCBI: 16977 Ensembl: ENSMUSG00000030125
Aliases leucine rich repeat containing 23
Synonyms 4921537K05Rik, B7, leucine rich repeat containing 23, LOC100911585, LRPB7, SPGF92
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrrc23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • leucine-rich repeat
  • protein phosphatase 1 regulatory subunit 42
  • Leucine rich repeat
  • protein binding
  • Leucine Rich repeats (2 copies)

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • major depression
  • hyperopia
  • progressive vision loss
  • corneal astigmatism
regulated by
role in cell
  • activation
  • motility
  • development
  • maintenance

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Cytoplasm
  • cytosol
  • sperm tail

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrrc23 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • cytoplasm
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.