Pcdhgc3 Gene Summary [Mouse]
Acts upstream of or within negative regulation of neuron apoptotic process and synapse organization. Located in membrane. Is expressed in brain. Orthologous to human PCDHGC3 (protocadherin gamma subfamily C, 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pcdhgc3 |
| Official Name | protocadherin gamma subfamily C, 3 [Source:MGI Symbol;Acc:MGI:1935201] |
| Ensembl ID | ENSMUSG00000102918 |
| Bio databases IDs | |
| Aliases | protocadherin gamma subfamily C, 3 |
| Synonyms | PC2, PC43, PCDH2, PCDH-GAMMA-C3, PCDH-γ-C3, protocadherin gamma subfamily C, 3, protocadherin γ subfamily C, 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcdhgc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- Cadherin-like
- ectodomain
- intracellular domain
- Cadherin repeat-like domain
- Cadherin cytoplasmic C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- intercellular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcdhgc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-dependent cell-cell adhesion
- synapse organization
- nervous system development
- cell adhesion
- homophilic cell adhesion
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding