Pcdha4 Gene Summary [Mouse]
Enables calcium ion binding activity and identical protein binding activity. Predicted to be involved in cell adhesion. Located in endoplasmic reticulum; membrane; and synapse. Is expressed in brain. Orthologous to human PCDHA4 (protocadherin alpha 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcdha4 |
| Official Name | protocadherin alpha 4 [Source:MGI Symbol;Acc:MGI:1298406] |
| Ensembl ID | ENSMUSG00000104252 |
| Bio databases IDs | |
| Aliases | protocadherin alpha 4 |
| Synonyms | CNR1, cnr5, CNRN1, CRNR1, LOC108348768, LOC120098166, Pcdha1, Pcdha10, Pcdha11, Pcdha12, Pcdha13, Pcdha2, Pcdha3, Pcdha5, Pcdha6, Pcdha7, Pcdha8, Pcdha9, Pcdhac1, Pcdhac2, PCDH-ALPHA4, protocadherin alpha 4, protocadherin α 4, rCNRv01, rCNRv02, rCNRv03, rCNRv05, rCNRv06, rCNRv07, rCNRv08, rCNRv09, rCNRv10, rCNRv11, rCNRv12, rCNRv13, rCNRvc1, rCNRvc2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcdha4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- Cadherin-like
- ectodomain
- calcium ion binding
- Cadherin repeat-like domain
- protein binding
- Cadherin cytoplasmic C-terminal
- extracellular cadherin structural domain
- identical protein binding
- Cadherin C-terminal cytoplasmic tail, catenin-binding region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- cell surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- synaptic membrane
- synapse
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcdha4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- cell adhesion
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcium ion binding