Gm28040 Gene Summary [Mouse]
Predicted to enable kisspeptin receptor binding activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; decidualization; and negative regulation of cell migration. Predicted to be located in apical plasma membrane; extracellular space; and neuronal cell body. Is expressed in diencephalon and metanephros. Used to study hypogonadotropic hypogonadism 13 with or without anosmia. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 13 with or without anosmia. Orthologous to human KISS1 (KiSS-1 metastasis suppressor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gm28040 |
| Official Name | predicted gene, 28040 [Source:MGI Symbol;Acc:MGI:5547776] |
| Ensembl ID | ENSMUSG00000115958 |
| Bio databases IDs | |
| Aliases | predicted gene, 28040 |
| Synonyms | Eseptin, Gm28040, HH13, KiSS-1 metastasis-suppressor, Kisspeptin, Kisspeptin-1, metastatin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gm28040 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- Kisspeptin
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- insulin resistance
- nonalcoholic fatty liver disease
- osteosarcomagenesis
- survival
- acute myeloid leukemia
- neurological disorder
- hypoplasia
- head and neck squamous cell carcinoma
role in cell
- apoptosis
- function in
- growth
- activation in
- proliferation
- expression in
- cell viability
- migration
- activation
- mass
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- apical membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gm28040 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of ovulation cycle rhythm
- positive regulation of growth hormone secretion
- cytoskeleton organization
- G-protein coupled receptor signaling pathway
- negative regulation of cell proliferation
- positive regulation of synaptic transmission
- positive regulation of luteinizing hormone secretion
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of MAPK cascade
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- neuronal cell body
- extracellular region
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- kisspeptin receptor binding