Kiss1r Gene Summary [Mouse]
Enables G protein-coupled peptide receptor activity. Acts upstream of or within negative regulation of cell migration; negative regulation of cell population proliferation; and signal transduction. Located in cell surface. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and thymus. Used to study hypogonadotropic hypogonadism 8 with or without anosmia. Human ortholog(s) of this gene implicated in central precocious puberty 1; hypogonadism; and hypogonadotropic hypogonadism 8 with or without anosmia. Orthologous to human KISS1R (KISS1 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Kiss1r |
| Official Name | KISS1 receptor [Source:MGI Symbol;Acc:MGI:2148793] |
| Ensembl ID | ENSMUSG00000035773 |
| Bio databases IDs | |
| Aliases | KISS1 receptor |
| Synonyms | AXOR12, CPPB1, GPR54, HH8, HOT7T175, KiSS-1, KISS1 receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kiss1r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- neuropeptide binding
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- neuropeptide receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Kiss1r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- breast cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- hypogonadotropic hypogonadism 8 without anosmia
- obesity
- hypoplasia
- hepatic steatosis
role in cell
- expression in
- activation in
- growth
- migration
- proliferation
- formation
- accumulation in
- phosphorylation in
- binding in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cilia
- cell surface
- intracellular space
- cellular membrane
- cell membrane leading edge
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kiss1r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane
- cilium
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled peptide receptor activity
- protein binding
- neuropeptide receptor activity