Kiss1r Gene Summary [Mouse]
Enables G protein-coupled peptide receptor activity. Acts upstream of or within negative regulation of cell migration; negative regulation of cell population proliferation; and signal transduction. Located in cell surface. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and thymus. Used to study hypogonadotropic hypogonadism 8 with or without anosmia. Human ortholog(s) of this gene implicated in central precocious puberty 1; hypogonadism; and hypogonadotropic hypogonadism 8 with or without anosmia. Orthologous to human KISS1R (KISS1 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Kiss1r |
| Official Name | KISS1 receptor [Source:MGI Symbol;Acc:MGI:2148793] |
| Ensembl ID | ENSMUSG00000035773 |
| Bio databases IDs | |
| Aliases | KISS1 receptor |
| Synonyms | AXOR12, CPPB1, GPR54, HH8, HOT7T175, KiSS-1, KISS1 receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kiss1r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- neuropeptide binding
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- neuropeptide receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Kiss1r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- breast cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- hypogonadotropic hypogonadism 8 without anosmia
- obesity
- hypoplasia
- hepatic steatosis
phenotypes
- abnormal bone structure
- abnormal epididymis morphology
- abnormal kidney morphology
- abnormal ovary morphology
- abnormal seminal vesicle morphology
- abnormal testis morphology
- absent epididymis
- absent ovary
- absent seminal vesicle
- absent testes
- absent uterus
- decreased body weight
- decreased bone mineral content
- decreased bone mineral density
- decreased heart weight
- decreased kidney weight
- decreased lean body mass
- decreased liver weight
- female infertility
- hypoactivity
- increased brain weight
- increased spleen weight
- increased total body fat amount
- male infertility
- prolonged QRS complex duration
- small kidney
- small superior vagus ganglion
- Leydig cell hypoplasia
- abnormal QRS complex
- abnormal adipose tissue amount
- abnormal adrenal cortex morphology
- abnormal anogenital distance
- abnormal blood homeostasis
- abnormal bone mineral density
- abnormal bone mineralization
- abnormal branching of the mammary ductal tree
- abnormal circulating glucose level
- abnormal female reproductive system morphology
- abnormal fertility/fecundity
- abnormal follicle stimulating hormone level
- abnormal heart weight
- abnormal hypothalamus morphology
- abnormal lean body mass
- abnormal locomotor activation
- abnormal male reproductive system morphology
- abnormal ovarian follicle morphology
- abnormal reproductive system morphology
- abnormal reproductive system physiology
- abnormal response/metabolism to endogenous compounds
- abnormal sexual interaction
- abnormal spermatid morphology
- absent corpus luteum
- absent estrous cycle
- absent male preputial gland
- absent mature ovarian follicles
- absent ovarian follicles
- absent prostate gland
- anovulation
- arrest of male meiosis
- arrest of spermatogenesis
- azoospermia
- constricted vagina orifice
- decreased adrenal gland weight
- decreased basophil cell number
- decreased circulating cholesterol level
- decreased circulating estradiol level
- decreased circulating follicle stimulating hormone level
- decreased circulating gonadotropin level
- decreased circulating insulin level
- decreased circulating luteinizing hormone level
- decreased circulating testosterone level
- decreased circulating total protein level
- decreased circulating triglyceride level
- decreased eosinophil cell number
- decreased epididymis weight
- decreased luteinizing hormone level
- decreased lymphocyte cell number
- decreased monocyte cell number
- decreased motor neuron number
- decreased neutrophil cell number
- decreased ovary weight
- decreased prostate gland weight
- decreased seminal vesicle weight
- decreased testis weight
- decreased uterus weight
- delayed sexual maturation
- delayed vaginal opening
- failure of ejaculation
- increased blood urea nitrogen level
- increased circulating alkaline phosphatase level
- increased circulating glucose level
- increased circulating serum albumin level
- increased thymus weight
- infertility
- mammary gland hypoplasia
- no abnormal phenotype detected
- preweaning lethality incomplete penetrance
- reduced male mating frequency
- retention of the adrenal gland x-zone
- seminal vesicle hypoplasia
- seminiferous tubule degeneration
- small epididymis
- small gonad
- small male preputial glands
- small ovary
- small penis
- small prostate gland
- small seminal vesicle
- small seminiferous tubules
- small testis
- small uterine cervix
- small uterus
- small vagina
- thrombocytopenia
- uterus hypoplasia
role in cell
- expression in
- activation in
- growth
- migration
- proliferation
- formation
- accumulation in
- phosphorylation in
- binding in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cilia
- cell surface
- intracellular space
- cellular membrane
- cell membrane leading edge
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kiss1r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane
- cilium
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled peptide receptor activity
- protein binding
- neuropeptide receptor activity