Tmem223 Gene Summary [Mouse]
Predicted to enable mitochondrial ribosome binding activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Is expressed in embryo. Orthologous to human TMEM223 (transmembrane protein 223). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem223 |
| Official Name | transmembrane protein 223 [Source:MGI Symbol;Acc:MGI:1914086] |
| Ensembl ID | ENSMUSG00000117924 |
| Bio databases IDs | |
| Aliases | transmembrane protein 223 |
| Synonyms | 0610006I08Rik, LOC686289, Mrx15, transmembrane protein 223 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem223 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribosome binding
- TMEM70/TMEM186/TMEM223 protein family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem223 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex IV assembly
- nervous system development
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- mitochondrial ribosome binding