Cdo1 Gene Summary [Rat]
Enables cysteine dioxygenase activity and ferrous iron binding activity. Involved in several processes, including L-cysteine catabolic process; lactation; and response to glucagon. Predicted to be located in cytosol. Biomarker of hypertension. Orthologous to human CDO1 (cysteine dioxygenase type 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdo1 |
| Official Name | cysteine dioxygenase type 1 [Source:RGD Symbol;Acc:69262] |
| Ensembl ID | ENSRNOG00000000158 |
| Bio databases IDs | |
| Aliases | cysteine dioxygenase type 1 |
| Synonyms | 1300002L19Rik, Cdo, CDO-I, cysteine dioxygenase 1, cytosolic, cysteine dioxygenase type 1, Cytosolic cysteine dioxygenase 1, D18Ucla3, LOC105379131 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- extracellular domain
- zinc ion binding
- nickel ion binding
- enzyme
- RmlC-like cupin superfamily
- cysteine dioxygenase
Pathways
Biological processes and signaling networks where the Cdo1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- neoplasia
- glioblastoma cancer
- colon adenocarcinoma
- colon epithelial cancer
- organismal death
- colon cancer
- esophageal cancer
- rheumatoid arthritis
- malocclusion
role in cell
- proliferation
- accumulation in
- apoptosis
- invasion by
- production in
- growth
- differentiation
- migration
- ferroptosis
- integrated stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to ethanol
- inflammatory response
- sulfur amino acid biosynthetic process
- response to glucocorticoid stimulus
- response to amino acid stimulus
- response to cAMP
- lactation
- response to glucagon stimulus
- cysteine metabolic process
- taurine biosynthetic process
- L-cysteine catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- cysteine dioxygenase activity
- ferrous iron binding
- nickel cation binding