Camk1 Gene Summary [Rat]
Enables calcium/calmodulin-dependent protein kinase activity. Involved in regulation of synapse organization. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human CAMK1 (calcium/calmodulin dependent protein kinase I). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Camk1 |
| Official Name | calcium/calmodulin-dependent protein kinase I [Source:RGD Symbol;Acc:629473] |
| Ensembl ID | ENSRNOG00000021781 |
| Bio databases IDs | |
| Aliases | calcium/calmodulin-dependent protein kinase I |
| Synonyms | calcium/calmodulin-dependent protein kinase I, Camk, Camk1,alpha, Camk1,α, CAMKI, CaMKIa, CaMKIalpha, CAM KINASE1, CaM kinase I, CaM kinase I α, D6Ertd263e, Gaip, KCC1A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Camk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- autoinhibitory protein domain
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- catalytic domain
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
- calmodulin regulated protein kinase
Pathways
Biological processes and signaling networks where the Camk1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- spondylarthritis
- infection by Dengue virus 2
role in cell
- phosphorylation in
- apoptosis
- autophagy in
- differentiation
- G1 phase
- development
- outgrowth
- growth
- organization
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- Nucleus
- cytosol
- postsynaptic density
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Camk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of syncytium formation by plasma membrane fusion
- positive regulation of protein export from nucleus
- signal transduction
- regulation of protein localization
- nervous system development
- positive regulation of dendritic spine development
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- negative regulation of protein binding
- regulation of muscle cell differentiation
- nucleocytoplasmic transport
- regulation of protein binding
- cell differentiation
- positive regulation of neuron projection development
- positive regulation of synapse structural plasticity
- peptidyl-serine phosphorylation
- positive regulation of protein serine/threonine kinase activity
- intracellular signal transduction
- positive regulation of muscle cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- intracellular
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- protein binding
- calmodulin-dependent protein kinase activity