Adamts14 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to act upstream of or within collagen fibril organization. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in osteoarthritis; primary progressive multiple sclerosis; and relapsing-remitting multiple sclerosis. Orthologous to human ADAMTS14 (ADAM metallopeptidase with thrombospondin type 1 motif 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamts14 |
| Official Name | ADAM metallopeptidase with thrombospondin type 1 motif, 14 [Source:RGD Symbol;Acc:1308899] |
| Ensembl ID | ENSRNOG00000000563 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase with thrombospondin type 1 motif, 14 |
| Synonyms | ADAM metallopeptidase with thrombospondin type 1 motif 14, ADAM metallopeptidase with thrombospondin type 1 motif, 14, TS14 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adamts14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Reprolysin family propeptide
- Thrombospondin type 1 domain
- ADAM-TS Spacer 1
- ZnMc
- ADAMTS cysteine-rich domain 2
- ADAMTS cysteine-rich domain
- peptidase
- Reprolysin (M12B) family zinc metalloprotease
- Spondin-like TSP1 domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adamts14 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- osteoarthritis
- spontaneous preterm birth
- breast carcinoma
- carpal tunnel syndrome
- periodontal pocket
- rhabdomyosarcoma
- soft tissue sarcoma cancer
- Dupuytren contracture
regulates
- Collagen(s)
- LOX
- Collagen type I (complex)
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adamts14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- extracellular matrix organization
- collagen catabolic process
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- metalloendopeptidase activity