Iscu Gene Summary [Rat]
Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; protein homodimerization activity; and transition metal ion binding activity. Predicted to be involved in several processes, including [2Fe-2S] cluster assembly; negative regulation of iron ion import across plasma membrane; and positive regulation of mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in cytosol and mitochondrion. Predicted to be part of mitochondrial [2Fe-2S] assembly complex. Predicted to be active in mitochondrial matrix. Orthologous to human ISCU (iron-sulfur cluster assembly enzyme). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Iscu |
| Official Name | iron-sulfur cluster assembly enzyme [Source:RGD Symbol;Acc:1309562] |
| Ensembl ID | ENSRNOG00000000701 |
| Bio databases IDs | |
| Aliases | iron-sulfur cluster assembly enzyme |
| Synonyms | 2310020H20Rik, HML, hnifU, iron-sulfur cluster assembly enzyme, iron-sulphur cluster assembly enzyme, ISCU1/2, ISCU2, ISU2, NIFU, NifU-like, NIFUN, RGD1309562 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Iscu often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- zinc ion binding
- protein homodimerization
- iron ion binding
- protein binding
- metallochaperone
- Iron-sulfur cluster scaffold-like proteins
Pathways
Biological processes and signaling networks where the Iscu gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioblastoma
- myopathy with exercise intolerance Swedish type
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- myopathy
- mitochondrial disorder
- glioblastoma cancer
- Parkinson disease
role in cell
- proliferation
- expression in
- cell death
- accumulation
- accumulation in
- oxidative stress response in
- lipoylation in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Iscu gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- [2Fe-2S] cluster assembly
- [4Fe-4S] cluster assembly
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- protein homodimerization activity
- iron ion binding
- ferrous iron binding
- 2 iron, 2 sulfur cluster binding
- binding, bridging