Clic2 Gene Summary [Rat]
Predicted to enable chloride channel activity and glutathione peroxidase activity. Predicted to be involved in chloride transport; negative regulation of ryanodine-sensitive calcium-release channel activity; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Orthologous to human CLIC2 (chloride intracellular channel 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clic2 |
| Official Name | chloride intracellular channel 2 [Source:RGD Symbol;Acc:1306580] |
| Ensembl ID | ENSRNOG00000000728 |
| Bio databases IDs | |
| Aliases | chloride intracellular channel 2 |
| Synonyms | chloride intracellular channel 2, CLCNL2, CLIC2b, MRXS32, XAP121 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clic2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- chloride channel
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- glutathione peroxidase
- intracellular chloride channel protein
Pathways
Biological processes and signaling networks where the Clic2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Clic2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- positive regulation of binding
- signal transduction
- chloride transport
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- negative regulation of ryanodine-sensitive calcium-release channel activity
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- nucleus
- cytoplasm
- membrane
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- glutathione peroxidase activity
- glutathione transferase activity
- chloride channel activity