RT1-M3-1 Gene Summary [Rat]
Predicted to enable CD8 receptor binding activity; peptide antigen binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of cytokine production; regulation of leukocyte differentiation; and regulation of lymphocyte mediated immunity. Predicted to act upstream of or within several processes, including antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; positive regulation of biosynthetic process; and response to bacterium. Predicted to be located in cis-Golgi network membrane; early endosome; and plasma membrane. Predicted to be part of MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in asthma and hepatitis C. Orthologous to human HLA-G (major histocompatibility complex, class I, G). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | RT1-M3-1 |
| Official Name | RT1 class Ib, locus M3, gene 1 [Source:RGD Symbol;Acc:3494] |
| Ensembl ID | ENSRNOG00000000763 |
| Bio databases IDs | |
| Aliases | RT1 class Ib, locus M3, gene 1 |
| Synonyms | 4B2/3.7, histocompatibility 2, M region locus 3, Hla-g, Hmt, M3a, MuprM3, MuprM301, MuprM302, R4B2, RanoM3, RanoM301, RanoM302, RT1 class Ib, locus M3, gene 1, RT1-M3, RT1-M3-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rt1-M3-1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- Class I Histocompatibility antigen, domains alpha 1 and 2
- CD8 receptor binding
- immunoglobulin domain
- protein homodimerization
- receptor binding
- identical protein binding
- peptide antigen binding
Pathways
Biological processes and signaling networks where the Rt1-M3-1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by bacteria
role in cell
- number
- abnormal morphology
- cytolysis by
- cytotoxicity
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
- early endosomes