Cbx5 Gene Summary [Rat]
Predicted to enable several functions, including histone H3K9me2/3 reader activity; histone deacetylase binding activity; and methylated histone binding activity. Predicted to be involved in DNA damage response; heterochromatin formation; and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in chromocenter; chromosome; and nuclear lumen. Predicted to be part of nucleoplasm; ribonucleoprotein complex; and transcription repressor complex. Predicted to be active in pericentric heterochromatin. Orthologous to human CBX5 (chromobox 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cbx5 |
| Official Name | chromobox 5 [Source:RGD Symbol;Acc:1306619] |
| Ensembl ID | ENSRNOG00000036841 |
| Bio databases IDs | |
| Aliases | chromobox 5 |
| Synonyms | 2610029O15Rik, chromobox 5, Chromobox homolog 5, HEL25, Heterochromatin1 alpha, Heterochromatin1 α, Heterochromatin protein 1 alpha, Heterochromatin protein 1 α, HP1, HP1A, HP1alpha, Hp1hs-α, HP1α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cbx5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- histone binding
- transcription regulator
- dimerization domain
- protein binding activity, bridging
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- common docking domain
- protein binding
- identical protein binding
- Chromo shadow domain
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- binding protein
- ribonucleoprotein binding
- hinge domain
- Chromo (CHRromatin organization MOdifier) domain
Pathways
Biological processes and signaling networks where the Cbx5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- male pattern hair loss
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- organismal death
- metabolic syndrome X
- cervical cancer
- high-grade cervical neoplasia
role in cell
- expression in
- apoptosis
- function
- differentiation
- binding in
- survival
- cohesion
- retention in
- recruitment in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- heterochromatic focus
- heterochromatin
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear envelope
- nuclear matrix
- PML nuclear bodies
- kinetochores
- centromeres
- telomeres
- chromatin
- euchromatin compartments
- pericentric heterochromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cbx5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- heterochromatin assembly
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- PML body
- histone methyltransferase complex
- histone deacetylase complex
- kinetochore
- nucleolus
- centromeric heterochromatin
- nucleoplasm
- nuclear envelope
- heterochromatin
- nucleus
- chromosome, telomeric region
- transcriptional repressor complex
- chromocenter
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- histone deacetylase binding
- methylated histone residue binding
- ribonucleoprotein complex binding
- chromatin binding
- protein binding, bridging