Dpys Gene Summary [Rat]
Enables several functions, including dihydropyrimidinase activity; pyrimidine nucleobase binding activity; and zinc ion binding activity. Involved in beta-alanine metabolic process; thymine catabolic process; and uracil catabolic process. Located in cytosol. Part of protein-containing complex. Human ortholog(s) of this gene implicated in dihydropyrimidinase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human DPYS (dihydropyrimidinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dpys |
| Official Name | dihydropyrimidinase [Source:RGD Symbol;Acc:68376] |
| Ensembl ID | ENSRNOG00000004298 |
| Bio databases IDs | |
| Aliases | dihydropyrimidinase |
| Synonyms | 1200017I10Rik, 1300004I01Rik, DHP, DHPase, dihydropyrimidinase, Hydantoinase, Ulip5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dpys often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- zinc ion binding
- dihydropyrimidinase
- dihydroorotase, multifunctional complex type
- Amidohydrolase family
- phosphoprotein binding
- enzyme
- metallo-dependent_hydrolases
- protein binding
- identical protein binding
- D-hydantoinase
- amino acid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- hallux valgus
- pigmented villonodular synovitis
- dihydropyrimidinase deficiency
- liver cancer
- Wilms tumor
- Wilms tumorigenesis
- hereditary disorder
- chronic obstructive pulmonary disease
regulates
- uracil
- dCMP
- dUMP
- pyrimidine base
- UMP
- beta-alanine
- thymine
- 5'-CMP
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dpys gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyrimidine base catabolic process
- dUMP catabolic process
- uracil catabolic process
- thymine catabolic process
- CMP catabolic process
- dCMP catabolic process
- UMP catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- protein binding
- phosphoprotein binding
- dihydropyrimidinase activity