Plod3 Gene Summary [Rat]
Predicted to enable hexosyltransferase activity; iron ion binding activity; and procollagen-lysine 5-dioxygenase activity. Involved in cellular response to hormone stimulus. Predicted to be located in trans-Golgi network. Predicted to be active in several cellular components, including Golgi apparatus; collagen-containing extracellular matrix; and endoplasmic reticulum. Biomarker of hypothyroidism. Orthologous to human PLOD3 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plod3 |
| Official Name | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 [Source:RGD Symbol;Acc:631339] |
| Ensembl ID | ENSRNOG00000001417 |
| Bio databases IDs | |
| Aliases | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 |
| Synonyms | BCARD, LH3, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plod3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- procollagen galactosyltransferase
- GT_LH
- metal ion binding
- procollagen-lysine 5-dioxygenase
- procollagen glucosyltransferase
- iron ion binding
- enzyme
- protein binding
- 2OG-Fe(II) oxygenase superfamily
- Prolyl 4-hydroxylase alpha subunit homologues
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lysyl hydroxylase 3 deficiency
- cerebral hemorrhage
- colorectal cancer
- colorectal neoplasm
- colorectal neoplasia
- growth failure
- SERPINH1 R222S mutation positive severe osteogenesis imperfecta
- cerebral amyloid angiopathy
- intrauterine growth retardation
- infection by HIV-1
role in cell
- formation
- organization
- abnormal morphology
- fragmentation
- hydroxylation in
- network formation in
- morphogenesis
- assembly
- diameter
- fibrillogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cell surface
- Extracellular Space
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- vitreal membranes
- trans Golgi network
- photoreceptor inner segments
- rough endoplasmatic reticulum
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plod3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- hydroxylysine biosynthetic process
- protein O-linked glycosylation
- protein localization
- vasodilation
- lung morphogenesis
- endothelial cell morphogenesis
- epidermis morphogenesis
- in utero embryonic development
- peptidyl-lysine hydroxylation
- basement membrane assembly
- collagen fibril organization
- collagen metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- trans-Golgi network
- extracellular space
- extracellular vesicular exosome
- rough endoplasmic reticulum
- Golgi apparatus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- procollagen galactosyltransferase activity
- L-ascorbic acid binding
- protein binding
- iron ion binding
- metal ion binding
- small molecule binding
- procollagen-lysine 5-dioxygenase activity
- procollagen glucosyltransferase activity