Aimp2 Gene Summary [Rat]
Predicted to enable molecular adaptor activity. Acts upstream of or within positive regulation of neuron apoptotic process. Part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 17. Orthologous to human AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aimp2 |
| Official Name | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 [Source:RGD Symbol;Acc:1560787] |
| Ensembl ID | ENSRNOG00000001044 |
| Bio databases IDs | |
| Aliases | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 |
| Synonyms | Aimp2(p38), aminoacyl tRNA synthetase complex-interacting multifunctional protein 2, HLD17, JTV-1, LOC100365507, P38 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aimp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- AIMP2 lysyl-tRNA synthetase binding domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- thioredoxin-like domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- motor dysfunction
- tumorigenesis
- lung cancer
- hereditary disorder
- survival
- hypomyelinating leukodystrophy type 17
- progression free survival
- Parkinson disease
role in cell
- expression in
- uptake in
- proliferation
- apoptosis
- ubiquitination in
- differentiation
- binding in
- transformation
- oncogene-induced senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aimp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- negative regulation of cell proliferation
- apoptotic process
- positive regulation of protein ubiquitination
- Type II pneumocyte differentiation
- translation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- cytosol
- aminoacyl-tRNA synthetase multienzyme complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- binding, bridging