Slc2a1 Gene Summary [Rat]
Enables several functions, including D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including D-glucose import; cellular response to mechanical stimulus; and dehydroascorbic acid transport. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of hypertension; hypothyroidism; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in childhood absence epilepsy; glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc2a1 |
| Official Name | solute carrier family 2 member 1 [Source:RGD Symbol;Acc:3704] |
| Ensembl ID | ENSRNOG00000007284 |
| Bio databases IDs | |
| Aliases | solute carrier family 2 member 1 |
| Synonyms | BAND 4.5, CSE, DYT17, DYT18, DYT9, EIG12, ERYTHROID/BRAIN GLUCOSE TRANSPORTER, GLUT, GLUT-1, GLUT1DS, Glut1r, GLUTB, GT1, GTG1, Gtg3, GTR1, HEPG2, HTLVR, M100200, PED, RATGTG1, Rgsc200, SDCHCN, solute carrier family 2 (facilitated glucose transporter), member 1, solute carrier family 2 member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc2a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hexose transporter
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- phosphate:H+ symporter
- protein binding
- organic anion transporter
- identical protein binding
- long-chain fatty acid transporter
- kinase binding
- Sugar (and other) transporter
- fucose transporter
- N-linked glycosylation site
- xenobiotic transporter
- transmembrane domain
- extracellular loop
- cytosolic tail domain
- transporter
Pathways
Biological processes and signaling networks where the Slc2a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- metastasis
- obesity
- stroke
- ST-elevation myocardial infarction
- chronic kidney disease
- heart failure
- non-insulin-dependent diabetes mellitus
- infection
- liver cancer
regulated by
- NFkB (complex)
- IL17A
- ibuprofen
- eicosapentaenoic acid
- lipopolysaccharide
- TCR (complex)
- benzyl isothiocyanate
- dexamethasone
- astrocytes
- Insulin
role in cell
- expression in
- production in
- proliferation
- survival
- apoptosis
- phosphorylation in
- function
- binding in
- cell death
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- exocytotic vesicle fractions
- microsomal fraction
- plasma membrane fraction
- high-density microsomal fractions
- intracellular membrane fractions
- low-density microsomal fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cortical actin cytoskeleton
- cholesterol-rich microdomain
- Cytoplasm
- presynaptic regions
- cell surface
- intracellular space
- perinuclear region
- intracellular membranes
- cellular membrane
- Nucleus
- vacuole
- vesicles
- midbody
- intercellular junctions
- cytosol
- lateral cell surfaces
- apical cell surfaces
- basolateral cell surfaces
- apical membrane
- caveolae
- basolateral membrane
- lateral plasma membrane
- Golgi membrane
- endosomal compartment
- pronucleus
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- sarcolemma
- Z line
- tight junctions
- microsomal membrane
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc2a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dehydroascorbic acid transport
- macromolecular complex assembly
- female pregnancy
- glucose import
- cerebral cortex development
- cellular response to glucose starvation
- cellular response to mechanical stimulus
- response to insulin stimulus
- central nervous system development
- response to hypoxia
- photoreceptor cell maintenance
- cellular hyperosmotic response
- xenobiotic transport
- L-ascorbic acid metabolic process
- plasma membrane long-chain fatty acid transport
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- plasma membrane
- female germ cell nucleus
- Z disc
- caveola
- extracellular vesicular exosome
- melanosome
- sarcolemma
- membrane
- blood microparticle
- intercalated disc
- cytosol
- midbody
- female pronucleus
- photoreceptor inner segment
- basolateral plasma membrane
- apical plasma membrane
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- identical protein binding
- protein binding
- D-glucose transmembrane transporter activity
- dehydroascorbic acid transporter activity
- glucose transmembrane transporter activity
- kinase binding
- long-chain fatty acid transporter activity