Rilpl2 Gene Summary [Rat]
Predicted to enable dynein light intermediate chain binding activity; identical protein binding activity; and small GTPase binding activity. Predicted to be involved in cilium assembly; epithelial cell morphogenesis; and protein transport from ciliary membrane to plasma membrane. Predicted to be located in several cellular components, including centrosome; cilium; and cytosol. Predicted to be active in ciliary basal body and cytoplasm. Orthologous to human RILPL2 (Rab interacting lysosomal protein like 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rilpl2 |
| Official Name | Rab interacting lysosomal protein-like 2 [Source:RGD Symbol;Acc:1303140] |
| Ensembl ID | ENSRNOG00000001061 |
| Bio databases IDs | |
| Aliases | Rab interacting lysosomal protein-like 2 |
| Synonyms | MGC7036, Rab interacting lysosomal protein-like 2, RLP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rilpl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rin homology domain
- Rab interacting lysosomal protein
- coiled-coil domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- lung adenocarcinoma
- Parkinson disease
- lung adenocarcinoma formation
- peripheral arterial disease
role in cell
- accumulation in
- morphogenesis
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cilia
- centrosome
- cytosol
- primary cilia
- apical cell surfaces
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rilpl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- epithelial cell morphogenesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- cilium basal body
- membrane
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- dynein light intermediate chain binding
- small GTPase binding
- protein dimerization activity