RILPL2 Gene Summary [Human]
This gene encodes a protein that contains a rab-interacting lysosomal protein-like domain. This protein may be involved in regulating lysosome morphology. This protein may also be a target for the Hepatitis C virus and assist in viral replication. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Details
| Type | Protein Coding |
| Official Symbol | RILPL2 |
| Official Name | Rab interacting lysosomal protein like 2 [Source:HGNC Symbol;Acc:HGNC:28787] |
| Ensembl ID | ENSG00000150977 |
| Bio databases IDs | |
| Aliases | Rab interacting lysosomal protein like 2 |
| Synonyms | MGC7036, Rab interacting lysosomal protein-like 2, RLP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RILPL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rin homology domain
- Rab interacting lysosomal protein
- coiled-coil domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- lung adenocarcinoma
- Parkinson disease
- lung adenocarcinoma formation
- peripheral arterial disease
role in cell
- accumulation in
- morphogenesis
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cilia
- centrosome
- cytosol
- primary cilia
- apical cell surfaces
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RILPL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- epithelial cell morphogenesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- cilium basal body
- membrane
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- dynein light intermediate chain binding
- small GTPase binding
- protein dimerization activity