Rilpl2 Gene Summary [Mouse]
Predicted to enable dynein light intermediate chain binding activity; identical protein binding activity; and small GTPase binding activity. Involved in epithelial cell morphogenesis and protein transport from ciliary membrane to plasma membrane. Located in centrosome and cilium. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human RILPL2 (Rab interacting lysosomal protein like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rilpl2 |
| Official Name | Rab interacting lysosomal protein-like 2 [Source:MGI Symbol;Acc:MGI:1933112] |
| Ensembl ID | ENSMUSG00000029401 |
| Bio databases IDs | |
| Aliases | Rab interacting lysosomal protein-like 2 |
| Synonyms | MGC7036, Rab interacting lysosomal protein-like 2, RLP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rilpl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rin homology domain
- Rab interacting lysosomal protein
- coiled-coil domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- lung adenocarcinoma
- Parkinson disease
- lung adenocarcinoma formation
- peripheral arterial disease
role in cell
- accumulation in
- morphogenesis
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cilia
- centrosome
- cytosol
- primary cilia
- apical cell surfaces
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rilpl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- epithelial cell morphogenesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- cilium basal body
- membrane
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- dynein light intermediate chain binding
- small GTPase binding
- protein dimerization activity