Myl12a Gene Summary [Rat]
Predicted to enable GTPase binding activity and glutamate receptor binding activity. Predicted to be involved in platelet aggregation. Predicted to act upstream of or within protein localization to plasma membrane and regulation of cell shape. Part of protein-containing complex. Orthologous to human MYL12A (myosin light chain 12A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myl12a |
| Official Name | myosin light chain 12A [Source:RGD Symbol;Acc:1309537] |
| Ensembl ID | ENSRNOG00000015278 |
| Bio databases IDs | |
| Aliases | myosin light chain 12A |
| Synonyms | 2900073G15Rik, myosin light chain 12A, myosin, light chain 12A, regulatory, non-sarcomeric, RGD1309537, Rlc-a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myl12a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- EF-hand domain pair
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- enzyme binding
- receptor binding
Pathways
Biological processes and signaling networks where the Myl12a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Axonal Guidance Signaling
- Cardiac Hypertrophy Signaling
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- CXCR4 Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- Gα12/13 Signaling
- Integrin Signaling
- PAK Signaling
- Phagosome Formation
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell cortex
- Z line
- actin stress fibers