Rplp0 Gene Summary [Rat]
Enables peptide binding activity. Involved in several processes, including cellular response to Thyroid stimulating hormone; cellular response to cAMP; and cellular response to phorbol 13-acetate 12-myristate. Is active in synapse. Biomarker of Down syndrome. Orthologous to several human genes including RPLP0 (ribosomal protein lateral stalk subunit P0). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rplp0 |
| Official Name | ribosomal protein lateral stalk subunit P0 [Source:RGD Symbol;Acc:621247] |
| Ensembl ID | ENSRNOG00000001148 |
| Bio databases IDs | |
| Aliases | ribosomal protein lateral stalk subunit P0 |
| Synonyms | 36B4, ACIDIC RIBOSOMAL PHOSPHOPROTEIN P0, AEG8, ARBP, L10E, LP0, P0, PRLP0, Ribo phosphoprotein P0, ribosomal protein lateral stalk subunit P0, RPP0, uL10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rplp0 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- 60s Acidic ribosomal protein
- Ribosomal_L10_P0
- Ribosomal protein L10
- structural constituent of ribosome
- Insertion domain in 60S ribosomal protein L10P
- domain II of P-stalk protein uL10
- protein binding
Pathways
Biological processes and signaling networks where the Rplp0 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myelodysplastic syndrome
- cholangiocarcinoma
- cholangiocarcinoma cancer
role in cell
- cell death
- phosphorylation in
- expression in
- apoptosis
- response by
- double-stranded DNA break repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- ribosomal fraction
- polyribosome fractions
- detergent resistant lipid raft fraction
- cytoplasmic ribonucleoprotein granule
- postsynaptic region
- cellular membrane
- ribosome
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- nucleoli
- synapse
- perikaryon
- dendrites
- postsynaptic density
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rplp0 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- ribosome biogenesis
- ribosomal large subunit assembly
- translation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- nucleus
- extracellular vesicular exosome
- focal adhesion
- cytosolic ribosome
- cytoplasm
- membrane
- cytosol
- endoplasmic reticulum
- cytosolic large ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome
- LSU rRNA binding