Kitlg Gene Summary [Rat]
Predicted to enable cytokine activity and stem cell factor receptor binding activity. Involved in ovarian follicle development and positive regulation of cell population proliferation. Predicted to be located in several cellular components, including extracellular space; filopodium; and lamellipodium. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Waardenburg syndrome; autosomal dominant nonsyndromic deafness 69; familial progressive hyperpigmentation with or without hypopigmentation; and pigmentation disease. Orthologous to human KITLG (KIT ligand). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kitlg |
| Official Name | KIT ligand [Source:RGD Symbol;Acc:3086] |
| Ensembl ID | ENSRNOG00000005386 |
| Bio databases IDs | |
| Aliases | KIT ligand |
| Synonyms | blz, C-kit ligand, Clo, Con, contrasted, DCUA, DFNA69, FPH1, FPH2, FPHH, Gb, HPP1, KITL, KIT ligand, KL-1, Mast cell factor, MGF, SCF, Scf164, SCF receptor LIGAND, SF, SHEP7, Sl, SLF, STEEL FACTOR, Stem cell factor, WS2F |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kitlg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stem cell factor receptor binding
- cytoplasmic domain
- transmembrane domain
- protein binding
- Stem cell factor
- cytokine
- growth factor
Pathways
Biological processes and signaling networks where the Kitlg gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- breast cancer
- epithelial cancer
- anemia
- chronic phase chronic myeloid leukemia
- acute lymphoblastic lymphoma
- accelerated phase chronic myelogenous leukemia
- primary T acute lymphoblastic leukemia
- gastrointestinal stromal tumor
- leukemia
role in cell
- survival
- adhesion
- chemotaxis
- phosphorylation in
- generation in
- damage in
- formation in
- migration
- proliferation
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- nuclear speckles
- filopodia
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kitlg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell programmed cell death
- male gonad development
- embryonic hemopoiesis
- positive regulation of cell proliferation
- positive regulation of Ras protein signal transduction
- Ras protein signal transduction
- cell adhesion
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of T cell proliferation
- response to organic cyclic compound
- positive regulation of melanocyte differentiation
- myeloid leukocyte differentiation
- hemopoietic progenitor cell differentiation
- ovarian follicle development
- positive regulation of myeloid leukocyte differentiation
- positive regulation of leukocyte migration
- neural crest cell migration
- mast cell proliferation
- T cell proliferation
- negative regulation of mast cell apoptotic process
- mast cell apoptotic process
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of mast cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoskeleton
- cytoplasm
- filopodium
- extracellular region
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- stem cell factor receptor binding
- cytokine activity