Tff1 Gene Summary [Rat]
Predicted to enable growth factor activity. Involved in several processes, including maintenance of gastrointestinal epithelium; response to immobilization stress; and response to iron ion. Located in extracellular space. Biomarker of colitis and gastric ulcer. Orthologous to human TFF1 (trefoil factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tff1 |
| Official Name | trefoil factor 1 [Source:RGD Symbol;Acc:620707] |
| Ensembl ID | ENSRNOG00000001164 |
| Bio databases IDs | |
| Aliases | trefoil factor 1 |
| Synonyms | BCEI, D21S21, HP1.A, HPS2, NEPHROCALCIN, pNR-2, PS2, TIFF1, trefoil factor 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tff1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Trefoil
Pathways
Biological processes and signaling networks where the Tff1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- cancer
- epithelial cancer
- organismal death
- breast carcinoma
- breast cancer
- ulceration
role in cell
- expression in
- proliferation
- invasion
- apoptosis
- colony formation by
- migration
- differentiation
- chemotaxis
- invasiveness
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tff1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- carbohydrate metabolic process
- signal transduction
- negative regulation of cell proliferation
- cell differentiation
- response to iron ion
- maintenance of gastrointestinal epithelium
- response to immobilization stress
- response to peptide hormone stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding