Ncoa3

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; nuclear receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including male gonad development; positive regulation of intracellular steroid hormone receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in perinuclear region of cytoplasm. Used to study breast cancer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NCOA3 (nuclear receptor coactivator 3). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ncoa3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Ncoa3 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Ncoa3 gene, providing context for its role in the cell.