Acads Gene Summary [Rat]
Enables FAD binding activity; acyl-CoA dehydrogenase activity; and protein homodimerization activity. Involved in fatty acid catabolic process; response to glucocorticoid; and response to starvation. Located in mitochondrial matrix and mitochondrial membrane. Human ortholog(s) of this gene implicated in alcohol use disorder and short chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADS (acyl-CoA dehydrogenase short chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acads |
| Official Name | acyl-CoA dehydrogenase short chain [Source:RGD Symbol;Acc:620514] |
| Ensembl ID | ENSRNOG00000001177 |
| Bio databases IDs | |
| Aliases | acyl-CoA dehydrogenase short chain |
| Synonyms | ACAD3, acyl-CoA dehydrogenase short chain, ACYL-COENZYME A DEHYDROGENASE, acyl-Coenzyme A dehydrogenase, short chain, Bcd-1, Hdlq8, SCAD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acads often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- flavin adenine dinucleotide binding
- short branched-chain acyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase, middle domain
- butyryl-CoA dehydrogenase
- enzyme
- protein binding
- identical protein binding
- FAD binding
- acyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase, C-terminal domain
- acyl-CoA binding
- protein homodimerization
- Acyl-CoA dehydrogenase, N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- obesity
- deficiency of butyryl-coa dehydrogenase
- colorectal cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- hereditary disorder
- microvesicular hepatic steatosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- low-density microsomal fraction
- centrosome
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
- nucleoplasm
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acads gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- fatty acid beta-oxidation using acyl-CoA dehydrogenase
- butyrate catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- mitochondrial matrix
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- acyl-CoA dehydrogenase activity
- flavin adenine dinucleotide binding
- butyryl-CoA dehydrogenase activity