Acads Gene Summary [Mouse]
This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the Acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum at C(four)-CoA. In mice, deficiency of this gene has been linked to cold sensitivity and increased high-density lipoprotein levels. [provided by RefSeq, Nov 2012]
Details
| Type | Retained Intron |
| Official Symbol | Acads |
| Official Name | acyl-Coenzyme A dehydrogenase, short chain [Source:MGI Symbol;Acc:MGI:87868] |
| Ensembl ID | ENSMUSG00000029545 |
| Bio databases IDs | |
| Aliases | acyl-Coenzyme A dehydrogenase, short chain |
| Synonyms | ACAD3, acyl-CoA dehydrogenase short chain, ACYL-COENZYME A DEHYDROGENASE, acyl-Coenzyme A dehydrogenase, short chain, Bcd-1, Hdlq8, SCAD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acads often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- flavin adenine dinucleotide binding
- short branched-chain acyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase, middle domain
- butyryl-CoA dehydrogenase
- enzyme
- protein binding
- identical protein binding
- FAD binding
- acyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase, C-terminal domain
- acyl-CoA binding
- protein homodimerization
- Acyl-CoA dehydrogenase, N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- obesity
- deficiency of butyryl-coa dehydrogenase
- colorectal cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- hereditary disorder
- microvesicular hepatic steatosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- low-density microsomal fraction
- centrosome
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
- nucleoplasm
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acads gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- fatty acid beta-oxidation using acyl-CoA dehydrogenase
- butyrate catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- mitochondrial matrix
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- acyl-CoA dehydrogenase activity
- flavin adenine dinucleotide binding
- butyryl-CoA dehydrogenase activity