Pcbp3 Gene Summary [Rat]
Predicted to enable C-rich single-stranded DNA binding activity and mRNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Orthologous to human PCBP3 (poly(rC) binding protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcbp3 |
| Official Name | poly(rC) binding protein 3 [Source:RGD Symbol;Acc:1307430] |
| Ensembl ID | ENSRNOG00000001245 |
| Bio databases IDs | |
| Aliases | poly(rC) binding protein 3 |
| Synonyms | ALPHA-CP3, PCBP3OT, PCBP3-OT1, Poly(rC)-binding protein 3, α-CP3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcbp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- K homology (KH) RNA-binding domain, type I
- KH domain
- single-stranded DNA binding
- protein binding
- K homology RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pcbp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- mRNA metabolic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- mRNA binding