Tnik Gene Summary [Rat]
Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of dendrite morphogenesis. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 54. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnik |
| Official Name | TRAF2 and NCK interacting kinase [Source:RGD Symbol;Acc:1561817] |
| Ensembl ID | ENSRNOG00000012422 |
| Bio databases IDs | |
| Aliases | TRAF2 and NCK interacting kinase |
| Synonyms | 1500031A17RIK, 4831440I19RIK, C530008O15Rik, C630040K21RIK, KIAA0551, MAP4K7, MRT54, RGD1561817, TRAF2 and NCK interacting kinase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnik often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- CNH domain
- central domain
- protein binding
- Protein kinase domain
- kinase
- germinal center kinase homology domain
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- intermediate domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastatic colorectal cancer
- Alzheimer disease
- androgenic alopecia
- schizophrenia
- metabolic syndrome X
- autosomal recessive mental retardation type 54
- peripheral arterial disease
- COVID-19
- frontotemporal dementia
role in cell
- cell death
- expression in
- growth
- quantity
- invasion by
- survival
- proliferation
- migration
- phosphorylation in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cytoskeleton
- organelle
- Cytoplasm
- presynaptic regions
- intracellular space
- perinuclear region
- Nucleus
- cytosol
- apical membrane
- nucleoplasm
- synaptic vesicles
- recycling endosomes
- filopodial tip
- postsynaptic density
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnik gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- cytoskeleton organization
- neuron projection morphogenesis
- protein autophosphorylation
- protein phosphorylation
- regulation of dendrite morphogenesis
- MAPK cascade
- positive regulation of JNK cascade
- positive regulation of protein phosphorylation
- microvillus assembly
- Wnt receptor signaling pathway
- actin cytoskeleton organization
- response to organic nitrogen
- protein localization in plasma membrane
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- extracellular vesicular exosome
- cytoplasm
- cytosol
- recycling endosome
- apical plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity