Cux2 Gene Summary [Rat]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of nervous system development; regulation of gene expression; and short-term memory. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 67. Orthologous to human CUX2 (cut like homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cux2 |
| Official Name | cut-like homeobox 2 [Source:RGD Symbol;Acc:1305967] |
| Ensembl ID | ENSRNOG00000001259 |
| Bio databases IDs | |
| Aliases | cut-like homeobox 2 |
| Synonyms | 1700051K22RIK, CDP2, CUTL2, cut-like homeobox 2, DEE67, EIEE67 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cux2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mechanosensitive ion channel porin domain
- flagellar export protein FliJ
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- CUT domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- nucleic acid binding
- sequence-specific DNA binding
- homeodomain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- insulin-dependent diabetes mellitus
- breast carcinoma
- hypertension
- atrial fibrillation
- Parkinson disease
- schizophrenia
- major depression
- coronary artery disease
- COVID-19
role in cell
- expression in
- number
- proliferation
- colony formation
- migration
- invasion by
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cux2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- short-term memory
- positive regulation of dendritic spine morphogenesis
- cognition
- positive regulation of gene expression
- positive regulation of excitatory postsynaptic membrane potential
- positive regulation of synapse assembly
- positive regulation of dendrite morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity