Cux2 Gene Summary [Mouse]
This gene is a member of the Cut family of transcription factors that have multiple DNA binding domains and regulate cell proliferation and differentiation. This gene is primarily expressed in nervous tissues where it controls the proliferation of neuronal precursors, and may play a role in organogenesis earlier during embryonic development. Mice lacking the encoded protein exhibit smaller spinal cords with deficits in neural progenitor development as well as in neuroblast and interneuron differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Cux2 |
| Official Name | cut-like homeobox 2 [Source:MGI Symbol;Acc:MGI:107321] |
| Ensembl ID | ENSMUSG00000042589 |
| Bio databases IDs | |
| Aliases | cut-like homeobox 2 |
| Synonyms | 1700051K22RIK, CDP2, CUTL2, cut-like homeobox 2, DEE67, EIEE67 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cux2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mechanosensitive ion channel porin domain
- flagellar export protein FliJ
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- CUT domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- nucleic acid binding
- sequence-specific DNA binding
- homeodomain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- insulin-dependent diabetes mellitus
- breast carcinoma
- hypertension
- atrial fibrillation
- Parkinson disease
- schizophrenia
- major depression
- coronary artery disease
- COVID-19
role in cell
- expression in
- number
- proliferation
- colony formation
- migration
- invasion by
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cux2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- short-term memory
- positive regulation of dendritic spine morphogenesis
- cognition
- positive regulation of gene expression
- positive regulation of excitatory postsynaptic membrane potential
- positive regulation of synapse assembly
- positive regulation of dendrite morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity