Snx5 Gene Summary [Rat]
Enables D1 dopamine receptor binding activity and phosphatidylinositol phosphate binding activity. Involved in epidermal growth factor catabolic process and negative regulation of blood pressure. Located in brush border and endosome. Orthologous to human SNX5 (sorting nexin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snx5 |
| Official Name | sorting nexin 5 [Source:RGD Symbol;Acc:1310190] |
| Ensembl ID | ENSRNOG00000006077 |
| Bio databases IDs | |
| Aliases | sorting nexin 5 |
| Synonyms | 0910001N05Rik, 1810032P22Rik, D2Ertd52e, sorting nexin 5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Snx5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- cytoskeletal protein binding
- amphipathic helix
- Vps5 C terminal like
- G-protein-coupled receptor binding
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- Bin/Amphiphysin/Rvs domain
- phosphatidylinositol binding
- PX domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- neoplasia
- epithelial cancer
- metastasis
- hepatocellular carcinoma
- liver cancer
- gastric cancer
- organismal death
- androgenic alopecia
role in cell
- expression in
- migration
- proliferation
- phosphorylation in
- activation in
- degradation in
- quantity
- autophagy in
- G1 phase
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- cytosol
- cytoplasmic face of plasma membrane
- early endosomes
- brush border
- cellular protrusions
- axon branches
- macropinosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Snx5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of insulin receptor signaling pathway
- positive regulation of transcription, DNA-dependent
- epidermal growth factor catabolic process
- regulation of macroautophagy
- negative regulation of blood pressure
- pinocytosis
- retrograde transport, endosome to Golgi
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- endosome
- perinuclear region of cytoplasm
- brush border
- retromer complex, outer shell
- intracellular membrane-bounded organelle
- retromer complex
- ruffle
- cytosol
- macropinocytic cup
- phagocytic cup
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- D1 dopamine receptor binding
- protein binding
- dynactin binding
- cadherin binding
- phosphatidylinositol binding
- phosphatidylinositol-5-phosphate binding
- phosphatidylinositol-3,5-bisphosphate binding