Marco Gene Summary [Rat]
Enables G protein-coupled receptor binding activity; amyloid-beta binding activity; and cargo receptor activity. Involved in several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; endocytosis; and positive regulation of ERK1 and ERK2 cascade. Located in cytoplasm and plasma membrane. Used to study silicosis. Biomarker of meningococcal meningitis. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human MARCO (macrophage receptor with collagenous structure). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Marco |
| Official Name | macrophage receptor with collagenous structure [Source:RGD Symbol;Acc:1589662] |
| Ensembl ID | ENSRNOG00000049303 |
| Bio databases IDs | |
| Aliases | macrophage receptor with collagenous structure |
| Synonyms | AI323439, Ly112, macrophage receptor with collagenous structure, MSR2, SCARA2, SR-A6, Sr-Marco |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Marco often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- cargo receptor activity
- signaling receptor activity
- G-protein-coupled receptor binding
- Collagen triple helix repeat (20 copies)
- beta-amyloid binding
- transmembrane receptor
- cysteine rich domain
- Scavenger receptor Cys-rich
Pathways
Biological processes and signaling networks where the Marco gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- COVID-19
- nonobstructive azoospermia
- hepatitis B virus-related hepatocellular carcinoma
- renal cell carcinoma
- renal cell cancer
- cutaneous sarcoidosis
- lung adenocarcinoma
role in cell
- production in
- morphology
- expression in
- binding
- formation
- phosphorylation in
- chemotaxis
- adhesion
- influx
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Marco gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- beta-amyloid clearance
- phagocytosis, engulfment
- innate immune response
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- apoptotic cell clearance
- cell surface receptor signaling pathway
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- collagen
- endocytic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- transmembrane signaling receptor activity
- cargo receptor activity
- beta-amyloid binding