Col4a1 Gene Summary [Rat]
Predicted to enable platelet-derived growth factor binding activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in epithelial cell differentiation. Predicted to be located in basement membrane. Predicted to be part of collagen type IV trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Biomarker of obesity and pulmonary hypertension. Human ortholog(s) of this gene implicated in brain small vessel disease 1; myocardial infarction; retinal arterial tortuosity; and uterine fibroid. Orthologous to human COL4A1 (collagen type IV alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Col4a1 |
| Official Name | collagen type IV alpha 1 chain [Source:RGD Symbol;Acc:1307148] |
| Ensembl ID | ENSRNOG00000016281 |
| Bio databases IDs | |
| Aliases | collagen type IV alpha 1 chain |
| Synonyms | BRU, BSVD, BSVD1, Col4alpha, Col4α, Col IV, Collagen type iv alpha1, collagen, type IV, alpha 1, collagen type IV alpha 1 chain, collagen, type IV, α 1, collagen type IV α 1 chain, PADMAL, procollagen type 4 alpha 1, procollagen type 4 α 1, RATOR, RAW, SVC, Type iv collagen alpha1 subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Col4a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular matrix structural constituent conferring tensile strength
- NC1 domain
- extracellular matrix structural constituent
- Collagen triple helix repeat (20 copies)
- C-terminal tandem repeated domain in type 4 procollagen
- protein binding
- growth factor binding
Pathways
Biological processes and signaling networks where the Col4a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- cardiovascular disorder
- neoplasia
- hereditary angiopathy with nephropathy, aneurysms, and muscle cramps
- porencephaly type 1
- experimentally-induced diabetes
- hereditary disorder
- coronary artery disease
- pontine autosomal dominant microangiopathy with leukoencephalopathy
- peripheral arterial disease
role in cell
- expression in
- migration
- transmigration
- organization
- anoikis
- development
- phosphorylation in
- retention in
- transdifferentiation
- retention
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- extracellular matrix
- exosomes
- plasma
- basement membrane
- glomerular basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Col4a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- neuromuscular junction development
- cellular response to amino acid stimulus
- renal tubule morphogenesis
- patterning of blood vessels
- extracellular matrix organization
- basement membrane organization
- blood vessel morphogenesis
- collagen-activated tyrosine kinase receptor signaling pathway
- brain development
- retinal blood vessel morphogenesis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- basement membrane
- extracellular region
- collagen type IV
Molecular Function
What the gene product does at the molecular level
- protein binding
- extracellular matrix structural constituent conferring tensile strength
- extracellular matrix structural constituent
- platelet-derived growth factor binding