Agps Gene Summary [Rat]
Enables alkylglycerone-phosphate synthase activity. Predicted to be involved in ether lipid biosynthetic process. Located in peroxisome. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata and rhizomelic chondrodysplasia punctata type 3. Orthologous to human AGPS (alkylglycerone phosphate synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agps |
| Official Name | alkylglycerone phosphate synthase [Source:RGD Symbol;Acc:620364] |
| Ensembl ID | ENSRNOG00000001547 |
| Bio databases IDs | |
| Aliases | alkylglycerone phosphate synthase |
| Synonyms | 5832437L22, 9930035G10Rik, ADAP-S, ADAS, ADHAPS, ADPS, Ads, ALDHPSY, alkylglycerone phosphate synthase, bs2, LOC100360503, RCDP3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Agps often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding
- FAD binding domain
- FAD linked oxidases, C-terminal domain
- alkylglycerone-phosphate synthase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- refractive error
- rhizomelic chondrodysplasia punctata, type 3
- diabetic nephropathy
- mammary neoplasm
- rhizomelic chondrodysplasia punctata
- astrocytosis
role in cell
- expression in
- proliferation
- growth
- survival
- utilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cytosol
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Agps gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid biosynthetic process
- ether lipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- membrane
- mitochondrion
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- FAD binding
- protein binding
- alkylglycerone-phosphate synthase activity