Ctsz Gene Summary [Rat]
Predicted to enable carboxypeptidase activity and cysteine-type endopeptidase activity. Predicted to be involved in epithelial tube branching involved in lung morphogenesis; negative regulation of plasminogen activation; and proteolysis involved in protein catabolic process. Located in several cellular components, including cell surface; extracellular space; and growth cone. Orthologous to human CTSZ (cathepsin Z). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctsz |
| Official Name | cathepsin Z [Source:RGD Symbol;Acc:708479] |
| Ensembl ID | ENSRNOG00000050697 |
| Bio databases IDs | |
| Aliases | cathepsin Z |
| Synonyms | Cathepsin X, Cathepsin Z, CATX, CTSX, D2Wsu143e |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctsz often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine-type peptidase
- cysteine endopeptidase
- carboxypeptidase
- catalytic domain
- peptidase
- RGD motif
- Peptidase_C1
- protein binding
Pathways
Biological processes and signaling networks where the Ctsz gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- breast cancer
- pancreatic neoplasia
- amyloidosis
- tauopathy
- breast carcinoma
role in cell
- expression in
- morphology
- proliferation
- migration
- production in
- invasion
- generation in
- invasiveness
- adhesion
- attachment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- perimembrane region
- intracellular membrane-bounded organelle
- secretory granule lumen
- ficolin-1-rich granule lumen
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- podosomes
- cell cortex
- Plasma Membrane
- lysosome
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- growth cone
- transport vesicles
- cytoplasmic vesicles
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctsz gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial tube branching involved in lung morphogenesis
- negative regulation of plasminogen activation
- proteolysis
- proteolysis involved in cellular protein catabolic process
- angiotensin maturation
Cellular Component
Where in the cell the gene product is active
- specific granule lumen
- endoplasmic reticulum
- extracellular region
- plasma membrane
- lysosome
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- cell cortex
- intracellular membrane-bounded organelle
- cytoplasmic vesicle
- ER to Golgi transport vesicle
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- carboxypeptidase activity
- protein binding
- cysteine-type endopeptidase activity
- cysteine-type peptidase activity