Rrm1 Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; disordered domain specific binding activity; and identical protein binding activity. Involved in several processes, including cell proliferation in forebrain; male gonad development; and response to ionizing radiation. Located in cell projection; neuronal cell body; and nuclear envelope. Human ortholog(s) of this gene implicated in chronic progressive external ophthalmoplegia. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rrm1 |
| Official Name | ribonucleotide reductase catalytic subunit M1 [Source:RGD Symbol;Acc:1592569] |
| Ensembl ID | ENSRNOG00000045752 |
| Bio databases IDs | |
| Aliases | ribonucleotide reductase catalytic subunit M1 |
| Synonyms | LOC100361270, PEOB6, R1, RIBONUCLEOTIDE REDUCTASE, ribonucleotide reductase catalytic subunit M1, RIBONUCLEOTIDE REDUCTASE M1, RIR1, RnrM1, RNR subunit R1, RR1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rrm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribonucleotide reductase and Pyruvate formate lyase
- Ribonucleotide reductase, barrel domain
- ribonucleoside-diphosphate reductase, alpha subunit
- Ribonucleotide reductase, all-alpha domain
- ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent
- protein domain specific binding
- enzyme
- protein binding
- purine nucleotide binding
- identical protein binding
- CH2 group:disulfide oxidoreductase
- ATP cone domain
- ribonucleoside-diphosphate reductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- invasive breast cancer
- metastatic invasive breast cancer
- metastatic breast cancer
- advanced breast cancer
- treatment-related acute myeloid leukemia
- acute myeloid leukemia
- HER2-positive breast cancer
- myeloproliferative disorder
- neoplasia
role in cell
- expression in
- cell viability
- apoptosis
- survival
- synthesis in
- proliferation
- phosphorylation in
- migration
- cell cycle progression
- progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- basal bodies
- centrosome
- Mitochondria
- cytosol
- nuclear envelope
- cellular protrusions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rrm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribonucleoside diphosphate metabolic process
- DNA repair
- male gonad development
- positive regulation of G1/S transition of mitotic cell cycle
- retina development in camera-type eye
- 2'-deoxyribonucleotide biosynthetic process
- cell proliferation in forebrain
- deoxyribonucleotide biosynthetic process
- mitochondrial DNA replication
- DNA synthesis involved in DNA repair
- protein heterotetramerization
- pyrimidine base metabolic process
- positive regulation of G0 to G1 transition
- response to ionizing radiation
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- mitochondrion
- cytosol
- neuronal cell body
- cell projection
- ribonucleoside-diphosphate reductase complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor