Esrp2 Gene Summary [Rat]
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within alternative mRNA splicing, via spliceosome; morphogenesis of a branching epithelium; and positive regulation of epithelial cell proliferation. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Orthologous to human ESRP2 (epithelial splicing regulatory protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Esrp2 |
| Official Name | epithelial splicing regulatory protein 2 [Source:RGD Symbol;Acc:1310855] |
| Ensembl ID | ENSRNOG00000023177 |
| Bio databases IDs | |
| Aliases | epithelial splicing regulatory protein 2 |
| Synonyms | 9530027K23Rik, epithelial splicing regulatory protein 2, FLJ21918, RBM35B, RGD1310855 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Esrp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- protein binding
Pathways
Biological processes and signaling networks where the Esrp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cleft lip
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
role in cell
- expression in
- proliferation
- migration
- signaling in
- splicing in
- cell-cell adhesion
- epithelial-mesenchymal transition
- motility
- alternative splicing by
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Esrp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial tube branching involved in lung morphogenesis
- epithelial cell proliferation
- regulation of RNA splicing
- alternative nuclear mRNA splicing, via spliceosome
- positive regulation of epithelial cell proliferation
- branching involved in salivary gland morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding