Atp5po Gene Summary [Rat]
Enables estradiol binding activity. Contributes to ATP hydrolysis activity. Involved in cellular response to cAMP and cellular response to cytokine stimulus. Located in cell surface. Part of proton-transporting ATP synthase complex. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 7. Orthologous to human ATP5PO (ATP synthase peripheral stalk subunit OSCP). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp5po |
| Official Name | ATP synthase peripheral stalk subunit OSCP [Source:RGD Symbol;Acc:621379] |
| Ensembl ID | ENSRNOG00000001991 |
| Bio databases IDs | |
| Aliases | ATP synthase peripheral stalk subunit OSCP |
| Synonyms | ATP5O, ATPO, Atp Synthase, H+ Transporting, Mitochondrial F1 Complex, O Subunit, Atp synthase-mitochondrial f1, ATP synthase peripheral stalk subunit OSCP, D12Wsu28e, HMC08D05, MC5DN7, OSCP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp5po often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PRK13429
- binding protein
- ATP synthase delta (OSCP) subunit
- H+-transporting two-sector ATPase
- protein binding
- hydrogen-transporting ATP synthase activity, rotational mechanism
- ATPase
- transporter
- steroid binding
Pathways
Biological processes and signaling networks where the Atp5po gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- hepatocellular carcinoma
- liver cancer
- mitochondrial complex V deficiency nuclear type 7
- Huntington disease
- chronic kidney disease
- metastasis
- Leigh syndrome
- infection by Rhesus rotavirus
role in cell
- apoptosis
- expression in
- growth
- transmembrane potential
- binding
- migration
- invasion by
- cohesion
- cohesion in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cristae-like membrane
- cell surface
- cellular membrane
- Nucleus
- Plasma Membrane
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp5po gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ATP biosynthetic process
- mitochondrial ATP synthesis coupled proton transport
- ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial proton-transporting ATP synthase, stator stalk
- mitochondrion
- plasma membrane
- mitochondrial inner membrane
- mitochondrial proton-transporting ATP synthase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen ion transporting ATP synthase activity, rotational mechanism