Cd38 Gene Summary [Rat]
Enables NAD+ nucleosidase activity, cyclic ADP-ribose generating. Involved in several processes, including blood vessel diameter maintenance; long-term synaptic depression; and negative regulation of bone resorption. Located in basolateral plasma membrane and nuclear membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd38 |
| Official Name | CD38 molecule [Source:RGD Symbol;Acc:2303] |
| Ensembl ID | ENSRNOG00000003069 |
| Bio databases IDs | |
| Aliases | CD38 molecule |
| Synonyms | ADPRC 1, ADP-ribosyl cyclase 1, cADPR1, CD38 ANTIGEN, CD38 molecule, Cd38-rs1, I-19 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd38 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38
- extracellular domain
- cytoplasmic domain
- N-glycosyl glycosylase
- transmembrane domain
- glycosylase
- enzyme
- identical protein binding
- phosphorus-oxygen lyase
Pathways
Biological processes and signaling networks where the Cd38 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- COVID-19
- neoplasia
- non-insulin-dependent diabetes mellitus
- obesity
- Huntington disease
- diabetes mellitus
- refractory multiple myeloma
- plasma cell myeloma
- relapsed multiple myeloma
role in cell
- quantity
- survival
- adhesion
- expression in
- cell viability
- growth
- production in
- accumulation in
- proliferation
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- soluble fraction
- detergent resistant lipid raft fraction
- cell surface
- cellular membrane
- Nucleus
- endosomes
- Endoplasmic Reticulum
- basolateral membrane
- inner nuclear membrane
- nuclear rim
- nuclear envelope
- nucleoplasts
- membrane rafts
- exosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd38 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to progesterone stimulus
- positive regulation of vasoconstriction
- apoptotic signaling pathway
- response to xenobiotic stimulus
- response to retinoic acid
- positive regulation of cell growth
- response to hypoxia
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of neuron projection development
- positive regulation of insulin secretion
- long term synaptic depression
- B cell receptor signaling pathway
- response to hydroperoxide
- signal transduction
- female pregnancy
- B cell proliferation
- negative regulation of bone resorption
- elevation of cytosolic calcium ion concentration
- negative regulation of apoptotic process
- response to interleukin-1
- response to estradiol stimulus
- NAD metabolic process
- positive regulation of B cell proliferation
- artery smooth muscle contraction
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- extracellular vesicular exosome
- membrane
- basolateral plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- NAD+ nucleosidase activity
- identical protein binding
- phosphorus-oxygen lyase activity
- transferase activity