Stim2 Gene Summary [Rat]
Enables calcium channel regulator activity. Involved in activation of store-operated calcium channel activity. Predicted to be active in endoplasmic reticulum and plasma membrane. Orthologous to human STIM2 (stromal interaction molecule 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stim2 |
| Official Name | stromal interaction molecule 2 [Source:RGD Symbol;Acc:1304641] |
| Ensembl ID | ENSRNOG00000002956 |
| Bio databases IDs | |
| Aliases | stromal interaction molecule 2 |
| Synonyms | stromal interaction molecule 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stim2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- STIM1 Orai1-activating region
- channel activation domain
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- calcium ion binding
- store-operated calcium channel
- protein binding
- calcium channel regulator
- transporter
Pathways
Biological processes and signaling networks where the Stim2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- eosinophilic esophagitis
- inguinal hernia
- growth failure
- experimental autoimmune encephalomyelitis
- nonfamilial Alzheimer disease
role in cell
- expression in
- proliferation
- function
- phosphorylation in
- activation in
- formation in
- binding in
- formation
- production in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- mushroom spine
- endoplasmic reticulum-plasma membrane junction
- stubby spine
- cellular membrane
- Endoplasmic Reticulum
- dense granule
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stim2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- store-operated calcium entry
- positive regulation of calcium ion transport
- calcium ion transmembrane transport
- activation of store-operated calcium channel activity
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- store-operated calcium channel activity
- protein binding
- calcium ion binding
- calcium channel regulator activity