Ppat Gene Summary [Rat]
Enables amidophosphoribosyltransferase activity and identical protein binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; glutamine catabolic process; and lactation. Biomarker of hepatocellular carcinoma and renal cell carcinoma. Orthologous to human PPAT (phosphoribosyl pyrophosphate amidotransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppat |
| Official Name | phosphoribosyl pyrophosphate amidotransferase [Source:RGD Symbol;Acc:620237] |
| Ensembl ID | ENSRNOG00000002128 |
| Bio databases IDs | |
| Aliases | phosphoribosyl pyrophosphate amidotransferase |
| Synonyms | 5730454C12RIK, AA408689, AA675351, ATASE, C79945, GPAT, phosphoribosyl pyrophosphate amidotransferase, PRAT |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutamine amidotransferase domain
- amidophosphoribosyltransferase
- Phosphoribosyl transferase (PRT)-type I domain
- enzyme
- protein binding
- identical protein binding
- Gn_AT_II
Pathways
Biological processes and signaling networks where the Ppat gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute lymphoblastic lymphoma
- interstitial lung disease
- precursor B-cell acute lymphoblastic leukemia
- inflammatory cardiomyopathy
- Philadelphia-like B-cell acute lymphoblastic leukemia
- leukemia
- acute lymphoblastic leukemia
- B-cell childhood acute lymphoblastic leukemia
- childhood acute lymphoblastic leukemia
- Crohn disease
regulates
- triacylglycerol
- purine nucleotide
- glutamine
- GMP
role in cell
- growth
- proliferation
- cell death
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 'de novo' AMP biosynthetic process
- purine nucleotide biosynthetic process
- 'de novo' IMP biosynthetic process
- glutamine metabolic process
- purine base biosynthetic process
- GMP biosynthetic process
- 'de novo' XMP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- amidophosphoribosyltransferase activity
- 4 iron, 4 sulfur cluster binding