Flnc Gene Summary [Rat]
Enables ankyrin binding activity. Predicted to be involved in sarcomere organization. Located in sarcolemma and sarcoplasm. Human ortholog(s) of this gene implicated in distal myopathy 4; hypertrophic cardiomyopathy 26; and myofibrillar myopathy 5. Orthologous to human FLNC (filamin C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Flnc |
| Official Name | filamin C [Source:RGD Symbol;Acc:1308807] |
| Ensembl ID | ENSRNOG00000007281 |
| Bio databases IDs | |
| Aliases | filamin C |
| Synonyms | 1110055E19RIK, ABP-280, ABP280A, ABPA, ABP-L, ARVC15, CMH26, filamin C, filamin C, gamma, filamin C, γ, Filamin gamma, Filamin γ, FLN2, gamma FILAMIN, MFM5, MPD4, RCM5, γ FILAMIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Flnc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Filamin/ABP280 repeat
- Calponin homology domain
- immunoglobulin domain
- protein binding
- identical protein binding
- actin-binding domain
- cytoskeletal protein binding
- ankyrin binding
- actin binding
- calponin homology (CH) domain superfamily
- hinge domain
- immunoglobulin-like protein domain
- Filamin-type immunoglobulin domains
Pathways
Biological processes and signaling networks where the Flnc gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- centronuclear myopathy
- filamin C-related myofibrillar myopathy
- endometrial cancer
- primary dilated cardiomyopathy
- distal myopathy type 4
- cardiomyopathy
- familial hypertrophic cardiomyopathy 26
- familial primary dilated cardiomyopathy
- cardiovascular disorder
role in cell
- morphology
- activation in
- quantity
- differentiation
- organization
- fusion
- number
- migration
- reorganization
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- soluble fraction
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- sarcoplasmic reticulum
- myofilaments
- costameres
- cytoplasmic bridges
- cytosol
- sarcoplasm
- sarcolemma
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Flnc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sarcomere organization
Cellular Component
Where in the cell the gene product is active
- Z disc
- intercellular bridge
- cytoskeleton
- focal adhesion
- sarcoplasm
- cytoplasm
- sarcolemma
- costamere
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- ankyrin binding
- cytoskeletal protein binding