Rras2 Gene Summary [Rat]
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to act upstream of or within Ras protein signal transduction and positive regulation of Schwann cell migration. Predicted to be located in endomembrane system. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome 12. Orthologous to human RRAS2 (RAS related 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rras2 |
| Official Name | RAS related 2 [Source:RGD Symbol;Acc:1310793] |
| Ensembl ID | ENSRNOG00000012258 |
| Bio databases IDs | |
| Aliases | RAS related 2 |
| Synonyms | 2610016H24Rik, NS12, RAS related 2, related RAS viral (r-ras) oncogene 2, TC21 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rras2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- CAAX box
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rras2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- Bladder Cancer Signaling
- BMP signaling pathway
- Chemokine Signaling
- CNTF Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- NF-κB Signaling
- Oncostatin M Signaling
- PAK Signaling
- PDGF Signaling
- PEDF Signaling
- PPAR Signaling
- Prolactin Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Thyroid Cancer Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- cancer
- Noonan syndrome
- COVID-19
- idiopathic membranous nephropathy
- recurrent breast cancer
- neoplastic cell transformation
- androgenic alopecia
- papillomatosis
role in cell
- activation in
- proliferation
- apoptosis
- transformation
- migration
- formation
- differentiation
- motility
- mitochondrial respiration
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- intracellular space
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rras2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Schwann cell migration
- osteoblast differentiation
- Ras protein signal transduction
- positive regulation of Schwann cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- membrane
- endoplasmic reticulum
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding