Gabrd Gene Summary [Rat]
Enables GABA-A receptor activity. Involved in chemical synaptic transmission. Located in plasma membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. Orthologous to human GABRD (gamma-aminobutyric acid type A receptor subunit delta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabrd |
| Official Name | gamma-aminobutyric acid type A receptor delta subunit [Source:RGD Symbol;Acc:61901] |
| Ensembl ID | ENSRNOG00000016385 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid type A receptor delta subunit |
| Synonyms | EIG10, EJM7, GABAA-RD, GABAARdelta, GABAA Receptor Delta Subunit, GABAA Receptor δ Subunit, Gaba receptor δ, gamma-aminobutyric acid (GABA) A receptor, subunit delta, gamma-aminobutyric acid type A receptor subunit delta, GEFSP5, γ-aminobutyric acid (GABA) A receptor, subunit δ, γ-aminobutyric acid type A receptor subunit δ |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gabrd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- LGIC_ECD
- neurotransmitter receptor
- channel/pore class transporter
- Neurotransmitter-gated ion-channel ligand binding domain
- intracellular domain
- protein binding
- extracellular ligand-gated ion channel
- ion channel
Pathways
Biological processes and signaling networks where the Gabrd gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- disorder of coronary artery
- epithelial cancer
- cancer
- renal cell cancer
- liver cancer
- plasma cell myeloma
- breast carcinoma
- invasive breast carcinoma
- invasive breast cancer
- schizophrenia
regulates
- ethanol
- Ro 15-4513
- GABRG2
- GABA-A receptor
- chloride
role in cell
- activity
- activation
- neurotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- perisynaptic region
- cellular membrane
- postsynaptic membrane
- synapse
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gabrd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- regulation of membrane potential
- signal transduction
- synaptic transmission
- synaptic transmission, GABAergic
- gamma-aminobutyric acid signaling pathway
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- dendrite
- postsynaptic membrane
- neuronal cell body
- synapse
- neuron projection
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- neurotransmitter receptor activity
- GABA-A receptor activity
- chloride channel activity