Ankrd17 Gene Summary [Rat]
Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of G1/S transition of mitotic cell cycle; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within blood vessel maturation and negative regulation of smooth muscle cell differentiation. Predicted to be located in chromatin and nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human ANKRD17 (ankyrin repeat domain 17). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ankrd17 |
| Official Name | ankyrin repeat domain 17 [Source:RGD Symbol;Acc:1562348] |
| Ensembl ID | ENSRNOG00000002940 |
| Bio databases IDs | |
| Aliases | ankyrin repeat domain 17 |
| Synonyms | 4933425K22Rik, A130069E23RIK, A930008M01, ankyrin repeat domain 17, ANR17, CAGS, circANKRD17, circRNA-ANKRD17, Foe, GTAR, Kiaa0697, Mask, MASK2, mKIAA0697, NY-BR-16, RGD1562348 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ankrd17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- UDM1_RNF168_RNF169-like
- Sperm tail
- Ankyrin repeats (3 copies)
- F-type ATP synthase, membrane subunit b
- chromatin binding
- K homology RNA-binding domain
- Proline-rich protein
- protein binding
- Ankyrin repeat
- ATP synthase archaeal, H subunit
- KH domain
- K homology (KH) RNA-binding domain, type I
- Domain of unknown function (DUF4200)
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Chopra-Amiel-Gordon syndrome
- lip and oral cavity carcinoma
- lip cancer
- hereditary disorder
- growth failure
- hypoplasia
- bleeding
- mental retardation
- hemopericardium
role in cell
- expression in
- differentiation
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear envelope
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ankrd17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of G1/S transition of mitotic cell cycle
- blood vessel maturation
- innate immune response
- positive regulation of MDA-5 signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of smooth muscle cell differentiation
- positive regulation of cell cycle
- regulation of DNA replication
- positive regulation of RIG-I signaling pathway
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasm
- membrane
- chromatin
- male germ cell nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- chromatin binding