Fgf3 Gene Summary [Rat]
Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; negative regulation of cardiac muscle tissue development; and positive regulation of MAPK cascade. Predicted to act upstream of or within several processes, including inner ear morphogenesis; post-anal tail morphogenesis; and thymus development. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and extracellular space. Orthologous to human FGF3 (fibroblast growth factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf3 |
| Official Name | fibroblast growth factor 3 [Source:RGD Symbol;Acc:620126] |
| Ensembl ID | ENSRNOG00000020888 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 3 |
| Synonyms | Fgf5c, fibroblast growth factor 3, HBGF-3, INT2, Int-P |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fgf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- nuclear localization sequence
- signal peptide
- protein binding
- nucleolar targeting motif
- growth factor
Pathways
Biological processes and signaling networks where the Fgf3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- hyperactive behavior
- cancer
- epithelial neoplasia
- epithelial cancer
- growth failure
- Michel aplasia with microtia and microdontia
- head and neck squamous cell cancer
- breast cancer metastatic to brain
- brain metastasis
role in cell
- phosphorylation in
- expression in
- proliferation
- survival
- differentiation
- transformation
- quantity
- growth
- cellular infiltration by
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- medial face of the Golgi apparatus
- dense fibrillar component
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fgf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of cell proliferation
- cell-cell signaling
- fibroblast growth factor receptor signaling pathway
- anatomical structure morphogenesis
- positive regulation of MAPK cascade
- organ morphogenesis
- positive regulation of cell division
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- cell differentiation
- negative regulation of cardiac muscle tissue development
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- fibroblast growth factor receptor binding