Serpinf2 Gene Summary [Rat]
Enables serine-type endopeptidase inhibitor activity. Involved in negative regulation of fibrinolysis. Located in extracellular space. Used to study acute necrotizing pancreatitis. Biomarker of familial hyperlipidemia. Human ortholog(s) of this gene implicated in COVID-19 and alpha-2-plasmin inhibitor deficiency. Orthologous to human SERPINF2 (serpin family F member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpinf2 |
| Official Name | serpin family F member 2 [Source:RGD Symbol;Acc:1306692] |
| Ensembl ID | ENSRNOG00000003233 |
| Bio databases IDs | |
| Aliases | serpin family F member 2 |
| Synonyms | A2AP, AAP, alpha2 ANTIPLASMIN, alpha2AP, ALPHA-2-PI, alpha 2 PLASMIN INHIBITOR, API, PLI, serine (or cysteine) peptidase inhibitor, clade F, member 2, Serpimf2, serpin family F member 2, α-2-PI, α 2 PLASMIN INHIBITOR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Serpinf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- protease binding
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- protein homodimerization
- protein binding
- Serpin (serine protease inhibitor)
Pathways
Biological processes and signaling networks where the Serpinf2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neurodegeneration
- non-insulin-dependent diabetes mellitus
- diabetic nephropathy
- psoriasis
- thrombolysis
- acute liver failure
- liver cancer
- myocardial infarction
- androgenic alopecia
role in cell
- proliferation
- growth
- differentiation
- activation
- binding
- outgrowth
- organization
- assembly
- invasion
- degradation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- alpha granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Serpinf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibrinolysis
- blood vessel morphogenesis
- positive regulation of cell differentiation
- fibrinolysis
- positive regulation of transcription from RNA polymerase II promoter
- regulation of blood vessel size by renin-angiotensin
- acute-phase response
- positive regulation of smooth muscle cell proliferation
- positive regulation of collagen biosynthetic process
- positive regulation of stress fiber assembly
- negative regulation of plasminogen activation
- positive regulation of JNK cascade
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of endopeptidase activity
- collagen fibril organization
- positive regulation of cell-cell adhesion mediated by cadherin
- positive regulation of transforming growth factor beta production
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- extracellular region
- cell surface
- fibrinogen complex
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- endopeptidase inhibitor activity
- protein homodimerization activity
- protein binding
- protease binding